Macrophages accumulate free cholesterol in advanced atherosclerotic lesions, resulting in macrophage apoptosis and progression of lesions 1,2,3,4,5,6,7,8. Previous studies with cultured macrophages ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly ...

Calcium is one of the most important minerals for body as well as cellular functions.But the way it controls the quality of ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

The endoplasmic reticulum plays a more important role in type 2 diabetes and its complications than previously believed, new research suggests. To make their discovery, scientists identified several ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

3D electron tomography reveals glycogen particles (purple) clustered on the surface of lipid droplets (yellow), closely associated with endoplasmic reticulum membranes (blue) and mitochondria (red), ...

Calcium-dependent phase separation of PDIA6. Top: Discovery of the "phase separation" phenomenon of PDIA6 in a test tube experiment: Addition of calcium to a PDIA6 solution leads to the formation of ...