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  1. Acetaminophen overdose - Symptoms, diagnosis and treatment | BMJ …

    Oct 15, 2025 · Summary Acetaminophen overdose may occur after an acute single ingestion of a large amount of acetaminophen or acetaminophen-containing drug formulations, or repeated ingestion of …

  2. Paracetamol overdose in adults - BMJ Best Practice

    Paracetamol overdose may occur after excessive ingestion of paracetamol or paracetamol-containing medication as an acute or staggered overdose, or therapeutic excess.Patients are often …

  3. Symptoms, diagnosis and treatment - BMJ Best Practice

    Benzodiazepine overdose can be intentional (e.g., as an act of self-harm), as part of recreational misuse, or accidental (e.g., medication error).Benzodiazepines are the most commonly prescribed …

  4. Symptoms, diagnosis and treatment - BMJ Best Practice

    Acute toxicity may occur in adults and children after ingestion of ≥125 mg/kg salicylate. [2] Chronic poisoning tends to occur after repeated exposure to high-dose aspirin, particularly in people with …

  5. Evaluation of metabolic acidosis - BMJ Best Practice

    Dec 23, 2025 · Differentials Common GI loss of bicarbonate Renal loss of bicarbonate - renal tubular acidosis type 1 and 2 Renal tubular acidosis type 4 Diabetic ketoacidosis Alcohol ketoacidosis …

  6. Digoxin toxicity - Symptoms, diagnosis and treatment | BMJ Best Practice

    Digoxin toxicity is a clinical diagnosis that relies in part on ECG findings such as signs of increased automaticity and atrioventricular node blockade (premature ventricular contractions, slowed …

  7. Symptoms, diagnosis and treatment - BMJ Best Practice

    Oct 3, 2025 · Lavonas EJ, Akpunonu PD, Arens AM, et al. 2023 American Heart Association focused update on the management of patients with cardiac arrest or life-threatening toxicity due to …

  8. Symptoms, diagnosis and treatment - BMJ Best Practice

    Nov 6, 2025 · Acute toxicity may occur after ingestion of a single dose of aspirin or the equivalent of >150 mg/kg or >6.5 g. [2] Chronic poisoning tends to occur as a result of repeated exposure to high …

  9. Cocaine toxicity - Symptoms, diagnosis and treatment | BMJ Best …

    Mar 25, 2025 · Cocaine toxicity occurs within minutes to hours of excessive cocaine use. Some patients may die suddenly before treatment is given. Presentation includes tachycardia, hypertension, …

  10. Digoxin toxicity - Symptoms, diagnosis and treatment - BMJ Best Practice

    Sep 12, 2025 · Digoxin toxicity can be acute or chronic, intentional, or accidental. Overdose can occur either intentionally or accidentally.Typically presents with components of gastrointestinal, …